PCT/US2013/027159

Systems and Methods for Purification and Concentration of Autologous Alpha-2 Macroglobulin (α2m) from Whole Blood

The present invention provides systems and methods for purification and concentration of autologous alpha-2 macroglobulin (α2m) from whole blood. Also provided are diagnostic methods for identifying sites in the synovial joints, spine, tendons or ligaments for treatment of pain, degeneration, or inflammation with autologous α2m. Methods for utilizing autologous α2m in combination with other autologous treatments (e.g. platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant α2m wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of α2m and/or to prolong the half-life of the protein in joints and spinal disc or epidural space.
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US9352021B2

Systems, Compositions, and Methods for Transplantation and Treating Conditions

The present invention provides systems and methods for purification and concentration of autologous alpha-2 macroglobulin (α2m) from whole blood and or recombinant α2m. Also provided are methods of treating wounds with α2m. Methods for utilizing α2m in combination with other treatments (e.g., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant α2m wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of α2m and/or to prolong the half-life of the protein for treating wounds.
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US9498514B2

Systems, Compositions, and Methods for Transplantation and Treating Conditions

The present invention provides systems and methods for purification and concentration of autologous alpha-2 macroglobulin (α2m) from whole blood and or recombinant α2m. Also provided are methods of treating wounds with α2m. Methods for utilizing α2m in combination with other treatments (e.g., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant α2m wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of α2m and/or to prolong the half-life of the protein for treating wounds.
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