As you can imagine, we get lots of questions. So, we took the time to answer them. Find answers to our most frequently asked questions below.

Product Information

What is Alpha2EQ?

Alpha2EQ provides the highest level of concentration of α2M in plasma available on the market today — up to five times more than naturally occurring levels. It is an orthobiologic device, which uses biological substances to help musculoskeletal injuries heal quicker. Orthobiologics are used to improve the healing of fractured bones and injured muscles, tendons and ligaments and are derived from substances that are naturally found in the body. Alpha2EQ is powered by the advanced, patented AlphaActive Concentrate Process.

How does it work?

Our breakthrough technology is based upon a naturally occurring molecule within the body. With Alpha2EQ, veterinarians can process and treat in just one hour with an uncomplicated three-step, minimally invasive procedure.

What kind of lameness does this therapy address?

Osteoarthritis (OA) can affect any horse at any age, and 60% of all equine lameness is related to osteoarthritis (USDA 2000, Caron 2003). OA is often associated with poor performance, early retirement, and a significant financial burden for owners of affected athletes (McIlwraith 2012).

How long does Alpha2EQ last?

The single-treatment, concentrated power of Alpha2EQ relieves lameness, inflammation and joint pain often for up to one year. However, there are several mitigating factors to the efficacy of the therapy, including the horse’s metabolism and the severity of the horse’s joint disease.

Are there any risks or side effect?

Risks may be considered inherent with any procedure or injection to a joint with any substance. However, there are no side effects to the orthobiologic procedure or Alpha-2 Macroglobulin when administered into a joint. Unlike steroid injection, there are no known long-term risks of Alpha2EQ therapy. It is also safe to use in joints that have previously been injected with other biologics or steroids.

How much does the Alpha2EQ Therapy costs?

Email us at [email protected] and we will be happy to get you to the right person to answer your questions about pricing and connecting you with a local veterinarian.

Does it work for every horse?

In a study, Alpha2EQ was found to be safe after 50 horses across five equine hospitals received joint injections for a variety of orthopedic conditions.

Where can I get the Alpha2EQ Therapy for my horse?

Alpha2EQ is only available through veterinarians. Veterinarians interested in learning more can contact KindredBio or visit for additional information.

You say you are the “only” Alpha-2 Macroglobulin concentrate therapy in the market. Is that true?

Alpha2EQ is the only orthobiologic device that is proven to isolate and concentrate α2M from plasma, intensifying the all-natural healing proteins of the horse’s own blood.

Is the AlphaActive (Alpha2) Concentrate Process patented?

Yes. AlphaActive is the only autologous process to concentrate α2M for mammals to obtain a U.S. patent. You can view all of our patents here.

How does Alpha2EQ compare to other PRP (platelet-rich plasma) or stem cell therapies?

AlphaActive is a highly improved process leveraging PRP methodology derivative of Platelet Poor Plasma (PPP) that concentrates plasma proteins from the equine patient’s own blood. Alpha2EQ provides the highest level of concentration of α2M in plasma available on the market today — up to five times more than naturally occurring levels.

If my horse already had a previous therapy, can we try Alpha2EQ?

Yes, this product is not contraindicated after using other orthobiologic therapies. It is an excellent choice to treat inflammation and normalizing an inflammatory environment as a pretreatment for regenerative therapies such as PRP and Stem Cells. Your veterinarian can discuss with you a treatment plan with Alpha2EQ.

How do I check my horse for lameness?

We always recommend that you check with your veterinarian to discuss both a diagnosis and treatment plan. If your vet has any questions about Alpha2EQ, please share with them what you’ve discovered about the power of concentrated Alpha-2 Macroglobulin (α2m).

How effective is the Alpha2EQ Therapy?

The results of the treatment can be observed within a few days of the procedure and have long-lasting effects of 6 or 12 months. Our process provides enough concentrate for 3-6 injections, depending on the injury site and veterinary technique. Excess concentrated α2M product can be frozen for future treatments.

I want to get the Alpha2EQ Therapy for my horse, but there is no veterinarian near me.

Please contact us at [email protected] and we will put you in touch with our closest Ambassador.

Can excess Alpha2EQ concentrate be frozen for future use?

Excess α2M from the injectate bag can be frozen for future treatments.

About Us

What does Astaria Global do?

We are a biotechnology company specializing in the development of diagnostics and therapeutics for osteoarthritis (OA), a disease of the joints that renders the afflicted immobile and in constant pain within the veterinarian space.

Why Astaria Global?

Glad you asked! Our name, Astaria, is pronounced “as-tar-ree-a” and is derived from a mash-up of the word “astra”, from the Latin etymology meaning “journey to the stars” and combined with the Latin “aria” meaning orchestral accompaniment. Thus, the name comes to mean “coming together in pursuit of something greater.” The journey of science led us to an amazing discovery that we are excited to share with the equine and companion animal lovers all over the world.

Why Alpha2EQ?

Our patented and advanced plasma technology isolates and concentrates the Alpha-2 Macroglobulin molecule. This is called the Alpha ActiveTM Concentrate Process. Our orthobiologic therapies use this process, which is specifically designed for inflammation and degeneration of joints in horses and companion animals. Alpha2EQ is specifically designed for horses; thus the “EQ” stands for equine in the name. We liked the idea of something simple, descriptive and easy to remember.

What studies have been done on this product?

We have conducted a clinical safety study and a proteomics equine study at Boise State University. The results of our research are available here.


I’m a veterinarian. How can I sell your products?

Contact us at [email protected] and we will put you in touch with our closest Ambassador. You can also visit for more information about joining our AstariaPlus Veterinarian Network.

Do you sell internationally?

We currently have product available in the USA, and have plans for additional markets in the not-so-distant future. We have lots of interest and are in discussions with selling product in Europe and Western Asia. Have an idea you would like to discuss? Feel free to reach out!

I need to get a copy of your logo for our marketing efforts.

Please visit to see a list of assets made available for use. Please note, restrictions apply for any of Astaria Global images, logos or information without prior written request for consent, approval prior to use and corporate notification of use that includes links, examples or copies of such use. Please contact [email protected] for more information. We are happy to help any way we can to extend our brand with partners, ambassadors, and media!