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Alpha-2-macroglobulin, a Native and Powerful Proteinase Inhibitor, Prevents Cartilage Degeneration Disease by Inhibiting Majority of Catabolic Enzymes and Cytokines
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Alpha-2-macroglobulin:
A Physiological Guardian
 Alpha-2-macroglobulin (a2M), a key member of alpha macroglobulin superfamily
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Identification of

Alpha-2-macroglobulin as a Master Inhibitor of Cartilage-Degrading Factors That Attenuates the Progression of Post traumatic Osteoarthritis (continue)

Alpha-2-macroglobulin, a Native and Powerful Proteinase Inhibitor, Prevents Cartilage Degeneration Disease by Inhibiting Majority of Catabolic Enzymes and Cytokines
(continue)

a2m Proteinase Inhibitor

Alpha-2-macroglobulin:
A Physiological Guardian
 Alpha-2- macroglobulin (a2M), a key member of alpha macroglobulin superfamily
(continue)

a2m Guardian

Identification of

Alpha-2-Macroglobulin as a Master Inhibitor of Cartilage-Degrading Factors That Attenuates the Progression of Post traumatic Osteoarthritis (continue)

Identification of a2m

Alpha-2-macroglobulin is unique in possessing a multi-modal mechanism of action — non-specific protease inhibition, cytokine and growth factor modulation, and gene regulation.  (continue)

Technical Bulletin

Alpha-2-macroglobulin is unique in possessing a multi-modal mechanism of action — non-specific protease inhibition, cytokine and growth factor modulation, and gene regulation 

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Based on the anti-inflammatory activity of A2M, and the ability to inhibit proteases, including collagenases, the molecule was considered as a potential new addition to the available means of managing equine recurrent uveitis (continue)

Human study demonstrates Alpha-2 Macro globulin shows similar effectiveness to corticosteroids in the treatment of knee osteoarthritis. Both A2M and corticosteroids appear to show better effectiveness than traditional PRP injection.

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