Alpha-2 Macroglobulin (α2M) is an exciting advancement in orthopedic science resulting from years of research.

Alpha-2 Macroglobulin (α2M) is a large glycoprotein, which is part of the innate immune system (Buresova 2009). It is naturally present in the joints of many species, including dogs and horses (Garner 2013, Cote 1998). α2M is unique in possessing a multi-modal mechanism of action— non-specific protease inhibition, cytokine and growth factor modulation, and gene regulation. It is a negative regulator of the catabolic factors associated with joint trauma and osteoarthritis. However, it is not present at sufficient levels to suppress all of the catabolic factors in an inflamed joint (Wang 2014). Our Alpha2EQ® is powered by our advanced, patented AlphaActive™ Concentrate Process. This highly improved process leverages PRP methodology derivative of Platelet Poor Plasma (PPP) that concentrates plasma proteins from the equine patient’s own blood, removing the harmful proteins that can remain in other autologous plasma products to allow for a pure α2M product with no inflammatory cytokines.